Evaluation of MoodGYM with an adolescent population.

263 V – ‘appetite and weight change’, VI – ‘anxiety’ and VII – ‘anergia’. A signifi cant therapeutic effect of lamotrigine in bipolar depression was found using the ‘depressive cognitions’ factor (from week 3) and ‘psychomotor retardation’ (from week 4). Conclusions: This study has identifi ed seven factors of the HDRS in a large sample of patients with bipolar depression. It suggests that the major effect of lamotrigine in bipolar depression is primarily upon central depressive cognitions and psychomotor disturbance.