Title: Efficacy of Single Dose Gentamicin in Combination with Metronidazole versus Multiple Doses for Prevention of Post Caesarean Infection Responses for Reviewer's Report
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چکیده
Title: Efficacy of single dose Gentamicin in combination with Metronidazole versus multiple doses for prevention of post caesarean infection Major points for revision Reviewer 1. The hypothesis being studied is that there is a difference in post-caesarean infections between a single dose of gentamicin in combination with metronidazole and multiple doses of gentamicin and metronidazole. In the background the authors reference two studies (24, 25) that demonstrate that
منابع مشابه
Efficacy of single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial
BACKGROUND Caesarean section is a commonly performed operation worldwide. It has been found to increase rates of maternal infectious morbidities more than five times when compared to vaginal delivery. Provision of intravenous prophylactic antibiotics 30 to 60 minutes prior to caesarean section has been found to reduce post-caesarean infection tremendously. Many centers recommend provision of a ...
متن کاملSingle dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection at Bugando Medical Centre in Mwanza, Tanzania: a randomized, equivalence, controlled trial
BACKGROUND Caesarean section(C/S) has been found to increase rates of maternal infectious morbidities five times more than vaginal delivery. The provision of intravenous prophylactic antibiotics 30 to 60 minutes prior to C/S has been found to substantially reduce post-caesarean infection. At Bugando Medical Centre, there is no consistent protocol for the administration of antibiotic prophylaxis...
متن کاملComparison of single versus multiple doses of antibiotic prophylaxis in reducing post-elective Caesarean section infectious morbidity.
BACKGROUND Puerperal sepsis is frequently in Caesarean section. Antibiotic prophylaxis may have significant impact in reduction of infections and thus the need to study its role in sepsis prevention systematically. OBJECTIVE The aim of this study is to compare the efficacy of single dose versus multiple doses of a first generation cephalosporin (with Metronidazole), to reduce postoperative in...
متن کاملProphylactic Antibiotic during Caesarean Sections at Komfo Anokye Teaching Hospital, Kumasi.
SUMMARY OBJECTIVES To compare the efficacy of co-amoxiclav (amoxicillin + clavulanic acid) and the triple therapy of ampicillin + gentamycin + metronidazole as prophylactic antibiotic during Caesarean sections. DESIGN A randomized controlled trial. SETTING The study was conducted between March and December 2002 at Komfo Anokye Teaching Hospital, Kumasi. PARTICIPANTS Patients undergoing ca...
متن کاملRisk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand
BACKGROUND No data currently exist about use of antibiotics to prevent surgical site infections (SSI) among patients undergoing appendectomy in Thailand. We therefore examined risk factors, use, and efficacy of prophylactic antibiotics for surgical site infection SSI among patients with uncomplicated open appendectomy. METHODS From July 1, 2003 to June 30, 2004 we conducted a prospective coho...
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تاریخ انتشار 2012