Granulomatous orchitis mimicking Hodgkin's lymphoma relapse.

The presence of granuloma in a biopsy specimen is not specific to sarcoidosis, and sarcoid-like granulomatous reaction can be found in chronic inflammatory, infectious and neoplastic diseases. Sarcoid reaction may occur in lymph nodes draining an area housing a malignant tumor, in the tumor itself and in nonregional tissues. Overall, sarcoid reaction occurs in 4.4% of cancers, 13.8% of patients with Hodgkin’s lymphoma and in 7.3% of cases with NHL. In some occasions sarcoid reactions may be extensive and may complicate the diagnosis of an underlying malignant disease. On the other hand, granulomatous reactions have been reported after drug therapy including anticancer chemotherapy. Here, we reported a case with granulomatous orchitis, which was diagnosed after 1 year of the completion of chemotherapy for Hodgkin’s lymphoma.