Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis.
نویسندگان
چکیده
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.
منابع مشابه
Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 58 1 شماره
صفحات -
تاریخ انتشار 2014