Infiltration of mast cells in pachydermia of pachydermoperiostosis
نویسندگان
چکیده
Dear Editor, Pachydermoperiostosis (PDP; Online Mendelian Inheritance in Man #614441) is a rare hereditary disease characterized by distinctive digital clubbing, periostosis and pachydermia. Patients with PDP harbor homozygous mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) or the 15-hydroxyprostaglandin dehydrogenase gene (HPGD), resulting in elevated prostaglandin E2 (PGE2) levels.
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