PReS-FINAL-2032: Changes in immunogenic profile in patients with juvenile idiopathic arthritis exposed to anti tumoral necrosis factor therapy
نویسندگان
چکیده
Introduction In a previous study conducted by our group we observed an unusual prevalence of tittles of antinuclear (ANA) and anti-DNA (aDNA) antibodies in children who were previously negative for both antibodies and who received any biologic therapy due to a childhood rheumatic systemic disease (CRSD). This observation has been reported in adulthood previously, mainly in patients exposed to anti tumoral necrosis factor (aTNF) therapy however its clinical impact is not well established.
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