Giant hypothalamic hamartoma and associated seizure types.

نویسندگان

  • A A Razzaq
  • M K Chishti
چکیده

Hypothalamic hamartomas are congenital malformations: consisting of disorganized, mature, neuronal elements in proportions, similar to that of normal tissue. The clinical presentation may include any combination of the following: asymptomatic, precocious puberty, behavioral disturbances and various types of seizures. The seizure pattern usually consists of laughing (gelastic seizures) beginning in early childhood, quite often in the first year of life. In later years, focal seizures dominate the pattern and often include complex partial seizures. This is finally followed by development of generalized tonic clonic seizures. Atonic seizures may also occur which may be confused with Lennox Gestaut syndrome. We present a case of a giant hypothalamic hamartoma which manifested itself with a reversed temporal sequence of epileptic subtypes, i.e. the patient had early onset of atonic seizures, followed by development of generalized tonic clonic seizures, and finally the appearance of laughing attacks typical of gelastic seizures. This report also briefly reviews current concepts of pathogenesis and the surgical options available for the control of epilepsy associated with hypothalamic hamartornas.

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عنوان ژورنال:
  • JPMA. The Journal of the Pakistan Medical Association

دوره 51 8  شماره 

صفحات  -

تاریخ انتشار 2001