Study on antibacterial root canal sealer containing chlorhexidine dihydrochloride. II. Investigation of antibacterial activity and follow-up study on clinical usage.

The in vitro antibacterial activity of K-20 prepared by addition of chlorhexidine dihydrochloride to a base sealer was compared with that of a manufactured product. The acute toxicity of K-20 was also investigated in the animals. The results demonstrated that K-20 prevents bacterial propagation without an unfavorable influence on the living tissue. K-20 was also evaluated clinically in cases of the root canal filling. Ninety three pulpless teeth filled with K-20 and guttapercha points and followed up for more than six months, were successful treated.