Virtual soybean—a computational model for studying autoregulation of nodulation
نویسندگان
چکیده
Introduction Nitrogen fixation by legumes is the product of a symbiosis of legume plants and a group of bacteria known as rhizobia (Carroll, et al., 1985; Kinkema, et al., 2006). It has been hypothesised that when rhizobia receive flavonoid signals from the host plants, production of a chemical nodulation factor is induced. The perception of nodulation factor by legume roots then activates a signal cascade leading to division of cortical cells for nodule formation. The activated cells produce a translocatable signal (Q), sent through a root-shoot pathway to the leaves and then detected by a leucine-rich repeat receptor kinase encoded by the NARK gene (Searle, et al., 2003). The detection of this root-shoot signal further induces the production of a shoot-derived signal (SDI) transported to the root, which inhibits development of new nodules. These signals, operating in a growing structure of root and shoot, compose a regulatory network known as autoregulation of nodulation (AON). The overall purpose of this study is to develop a greater understanding of this system through multi-scale modelling of processes including intraand inter-cellular signalling, long-distance signalling and phenotypic development regulated by internal control mechanisms. The first step is to build a structural framework capable of simulating soybean growth driven by empirical results and hypothetical patterns, incorporating control mechanisms modelling Q and SDI.
منابع مشابه
Computational Complementation: A Modelling Approach to Study Signalling Mechanisms during Legume Autoregulation of Nodulation
Autoregulation of nodulation (AON) is a long-distance signalling regulatory system maintaining the balance of symbiotic nodulation in legume plants. However, the intricacy of internal signalling and absence of flux and biochemical data, are a bottleneck for investigation of AON. To address this, a new computational modelling approach called "Computational Complementation" has been developed. Th...
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