A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress
نویسندگان
چکیده
Comment on: Joaquin M, et al. EMBO J 2012; 31:2952-64.
منابع مشابه
The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress
The p57(Kip2) cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but little is known of its role in cell cycle control. Here, we show that p57(Kip2) is targeted by the p38 stress-activated protein kinase (SAPK). Phosphorylation of p57(Kip2) at T143 by p38 enhances its association with and inhibition of Cdk2, which results in cell...
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