Effect of antacids in didanosine tablet on bioavailability of isoniazid.
نویسندگان
چکیده
The antacids in two didanosine placebo tablets had no significant effect on the plasma pharmacokinetics of a single oral dose of 300 mg of isoniazid administered to 12 healthy volunteers. These results suggest that isoniazid bioavailability will be unaffected by the antacids in didanosine tablets when the two medications are administered simultaneously to human immunodeficiency virus-seropositive patients.
منابع مشابه
DAMLE ET AL BIOEQUIVALENCE OF DIDANOSINE FORMULATIONS PHARMACOKI ETICS AND PHARMACODYN MICS Bioequivalence of Two Formulations of Didanosine, Encapsulated Enteric-Coated Beads and Buffered Tablet, in Healthy Volunteers and HIV-Infected Subjects
D is a purine nucleoside analog that is indicated for the treatment of human immunodeficiency virus (HIV) infection. It has been administered orallywith antacids toprotect against acid-inducedhydrolysis in the stomach. Formulations of didanosine that are currently available as buffered products or are intended to be used with buffer include the buffered powder for oral solution, chewable/disper...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 38 4 شماره
صفحات -
تاریخ انتشار 1994