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ACCOMPLISHMENTS (throughout the award period): We first established the model system for analyzing IgEand mast cell-dependent cutaneous allergic reactions in wild type (normal) mice of the correct genetic background (129/Sv x C57BL/6 mice), since the details of the methods needed for optimal analysis of such reactions can vary according to mouse strain. We then analyzed multiple features of IgEand mast cell-dependent cutaneous reactions in mice that genetically lack P-selectin (P -/-), E-selectin (E -/-), or both of these selectins (P/E -/-) to investigate the possible roles of the selectins in the pathogenesis of these reactions. We found that a lack of either or both selectins had little or no effect on the extent of mast cell degranulation or the tissue swelling associated with these reactions. Moreover, a lack of either Por E-selectin alone did not reduce the leukocyte (primarily, neutrophil) infiltration at the reaction sites. However, mice lacking both Pand E-selectins exhibited an almost complete ablation of IgEand mast celldependent neutrophil recruitment. These findings, which show that Pand E-selectins can express overlapping functions in leukocyte recruitment associated with IgEand mast celldependent cutaneous late phase reactions in mouse skin, were published in Laboratory Investigation in April, 1998 (publication 1 on the attached list).
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تاریخ انتشار 1999