Study of gastrointestinal toxicity of selective COX-2 inhibitors in comparison with conventional NSAIDs
نویسنده
چکیده
Non-steroidal antiinflammatory drugs presently are the most widely used drugs in medicine and their annual sales in the world are more than 6 billion dollars. Presently, more than 100 NSAIDs have been tested clinically and more than 50 are there in the world market. Nearly 35 million people are taking them on daily basis and FDA has ranked them the most frequent cause of adverse drug reactions. 1 The spectrum of adverse reactions is broad. The most frequent problems are gastrointestinal, the most common being dyspepsia. Dyspepsia is a common symptom of gastrointestinal complications of NSAIDs use and is usually complained by about 10-12% of patients taking NSAIDs. Dyspepsia may lead to non-compliance with NSAID therapy in 5-15% of patients. 2
منابع مشابه
Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
متن کاملSelective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
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