Evaluation of Echinococcus multilocularis Tetraspanins as Vaccine Candidates against Primary Alveolar Echinococcosis Running title: Echinococcosis Tetraspanin Vaccination
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چکیده
Title Evaluation of Echinococcus multilocularis tetraspanins as vaccine candidates against primary alveolar echinococcosis Author(s) Dang, Zhisheng; Yagi, Kinpei; Oku, Yuzaburo; Kouguchi, Hirokazu; Kajino, Kiichi; Watanabe, Junichi; Matsumoto, Jun; Nakao, Ryo; Wakaguri, Hiroyuki; Toyoda, Atsushi; Sugimoto, Chihiro Citation Vaccine, 27(52): 7339-7345 Issue Date 2009-12-09 Doc URL http://hdl.handle.net/2115/42601 Type article (author version)
منابع مشابه
Evaluation of Echinococcus multilocularis tetraspanins as vaccine candidates against primary alveolar echinococcosis.
Echinococcus multilocularis causes an important zoonotic cestode disease. The metacestode stage proliferates in the liver of intermediate hosts including human and rodents and forms multiple cysts. Recently, members of a transmembrane protein tetraspanin (TSP) family have been used as vaccines against schistosomosis, or as diagnostic antigens for cysticercosis. In this study, seven tetraspanins...
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BACKGROUND We have previously evaluated the vaccine efficacies of seven tetraspanins of Echinococcus multilocularis (Em-TSP1-7) against alveolar echinococcosis (AE) by subcutaneous (s.c.) administration with Freund's adjuvant. Over 85% of liver cyst lesion number reductions (CLNR) were achieved by recombinant Em-TSP1 (rEm-TSP1) and -TSP3 (rEm-TSP3). However, to develop an efficient and safe hum...
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Alveolar echinococcosis (AE) caused by Echinococcus multilocularis can infect humans as a dead-end host. They matured in canid’s intestine (e.g. foxes, jackals, wolves, dogs, cats, etc.). AE is seen across the world. It has a high prevalence in the central and northern parts of Europe, North America and Asia. The prevalence of AE was low in the past, even in hyper endemic regions. But in ...
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Alveolar echinococcosis of the liver can be mistaken as a liver tumor. The occurrence of the fox tapeworm echinococcus multilocularis is increasing in formerly unaffected European regions. As a consequence, alveolar echinococcosis is becoming an important differential diagnosis in Eastern and Northern Europe.
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Echinococcus multilocularis, the causative agent of human alveolar echinococcosis, is reported for the first time in Red Foxes (Vulpes vulpes) in Hungary. This parasite may be spreading eastward because the population of foxes has increased as a consequence of human interventions, and this spread may result in the emergence of alveolar echinococcosis in Central Eastern Europe.
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