Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
نویسندگان
چکیده
Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient preference.
منابع مشابه
Alterations to Taste Preference in MC4R Haploinsufficiency Manifest Prior to Dietary Induced Obesity and Are Accompanied by Dendritic Spine Alterations to Medium Spiny Neurons of the Nucleus Accumbens in Adulthood
Moran for their assistance in data collection and analysis. ABSTRACT Obesity has reached epidemic proportions in the United States and has become an increasing public health concern for developed nations. Haploinsufficiency of melanocortin receptor 4 has been identified as the single most common monogenetic cause of obesity in humans. Using the MC4R +/-haploinsufficient rat, we sought to determ...
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