In vitro evaluation of guanidine analogues as sigma receptor ligands for potential anti - stroke therapeutics
نویسندگان
چکیده
Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, 12901 Bruce B. Downs Blvd., MDC-9, Tampa, FL 33612 U.S.A. (AAB, JC) Department of Chemistry, University of South Florida, College of Arts and Sciences, 4202 E. Fowler Ave., CHE 205A, Tampa, FL 33620 (MCS, JCA) Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA (MJS, RRM) JPET Fast Forward. Published on October 12, 2012 as DOI:10.1124/jpet.112.199513
منابع مشابه
In vitro evaluation of guanidine analogs as sigma receptor ligands for potential anti-stroke therapeutics.
Currently, the only Food and Drug Administration-approved treatment of acute stroke is recombinant tissue plasminogen activator, which must be administered within 6 hours after stroke onset. The pan-selective σ-receptor agonist N,N'-di-o-tolyl-guanidine (o-DTG) has been shown to reduce infarct volume in rats after middle cerebral artery occlusion, even when administered 24 hours after stroke. D...
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تاریخ انتشار 2012