Effect of a Dietary Supplement Containing Raspberry Ketone on Cytochrome P450 3A Activity

Destructive effect of quinone-containing compounds on cytochrome P450: Arbutin as a double-edged sword

Effects of ingesting Dyma-Burn Xtreme, a thermogenic dietary supplement on metabolic rate and subjective measures of mood state

Background Many supplements on the market today contain ingredients that claim to increase metabolism and enhance fat loss. Green tea extract and caffeine have well known thermogenic properties. The purpose of this study was to evaluate the effects of proprietary thermogenic dietary supplement Dyma-Burn Xtreme, containing a blend of ingredients including caffeine, green tea extract, raspberry k...

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method

Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo. Materials and Methods: Fourteen days after intraperitoneal injection of lentinan, rats were given an oral dose of a cocktail solution containing phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam...

In vitro hepatotoxicity and cytochrome P450 induction and inhibition characteristics of carnosic acid, a dietary supplement with antiadipogenic properties.

Carnosic acid is a phenolic diterpene isolated from rosemary (Rosmarinus officinalis), which may have anticancer, antiadipogenic, and anti-inflammatory properties. Recently, carnosic acid was shown to prevent weight gain and hepatic steatosis in a mouse model of obesity and type II diabetes. Based on these results, carnosic acid has been suggested as a potential treatment for obesity and nonalc...

Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion

A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...