Molecular Perfusion Imaging with 99mTc-MIBI Lower Limb Muscle SPECT: In Diagnosis and Follow up of Peripheral Arterial Diseases (PAD)

Results: In SPECT study visual analysis correlated extremely well with clinical features. Comparison of patient SPECT data with normal population showed significant hypoperfusion of lower limbs in terms of counts (P-value <0.001). Follow up of patients (N=12) showed significant improvement of muscle perfusion in nine patients while three patients showed no improvement. Comparison of follow up planar study values with baseline were not conclusive for any improvement in limb perfusion (p-value ~ 0.98). Comparison of SPECT study with other modalities showed higher sensitivity than Doppler ultrasound (P-value <0.05), ABI (p-value <0.001) and planar scan (p-value <0.001) The sensitivity, specificity, positive predictive values and negative predictive values are 93%, 100%, 100%, 92% for 99mTc-MIBI; 64%, 100%, 100%, 69% for ABI; 77%, 100%, 100%, 78.3% for Doppler ultrasound and 75%, 100%, 100%, 76.6% for Planar scan respectively.