Guillain-Barre Syndrome Associated with Gastric Cancer: Paraneoplastic Syndrome or Immunological Disorder?
نویسندگان
چکیده
Guillain-Barre syndrome is a rare clinical entity classified as an ascending muscle paralysis led by autonomic nervous dysfunction due to autoimmune damage of peripheral nerves. Paraneoplastic Guillain-Barre syndrome has been described in association with some kinds of tumors (B-cell Lymphoma and small cell lung cancer). We describe the case of a 74-year-old woman affected by gastric adenocarcinoma, treated with surgery and adjuvant chemotherapy, who developed simultaneously skin cancer relapse and severe Guillain-Barre syndrome. Although the timing of clinical presentation suggests a paraneoplastic origin, other interesting features were present in this patient such as familial and personal anamnesis for autoimmune disease, HCV infection, and neurotoxic chemotherapy. According to literature, we investigated different pathogenetic hypothesis. According to the poorness of data, further investigations are necessary to establish a relationship between Guillain-Barre syndrome and gastric cancer.
منابع مشابه
Carcinoid Tumor-Associated Paraneoplastic Polyneuropathy that Mimics Guillain-Barre Syndrome.
Paraneoplastic polyneuropathies are among the most common distal neurological complications of systemic cancer on the nervous system. All peripheral neuropathy types, such as demyelinating, axonal, motor, sensory, or autonomic, can present in association with cancer and can have a paraneoplastic etiology (1). Classical paraneoplastic peripheral neuropathy is typically a sensory neuropathy with ...
متن کاملGuillain-Barre’ Syndrome: A Case Report
Background and Objectives: Guillain-Barre´ Syndrome (GBS) is an acute-onset, monophasic, immune-mediated polyneuropathy that often follows an antecedent infection. Special nutritional support has an important role in these patients. Methods: A 6 years old girl with GBS was admitted to PICU of Dr. Sheikh Children Hospital (Mashhad, Iran). Chief compliance for hospitalization was inability to w...
متن کاملA Case Report of Guillain – Barre - Like Syndrome Associated With Olanzapine Hypersensitivity Reaction
Introduction: Olanzapine (Zyprexa) has become one of the most commonly prescribed atypical antipsychotic drug in Iran, at least in part due to its low potential to cause extra-pyramidal side effects. Case: A 54-year-old man, who was a known case of schizophrenia from 10 years ago and within the recent years, was under periodic medical treatment by antipsychotic drugs. Conclusion: Neurologi...
متن کاملTen-year Investigation of Clinical and Laboratory Findings in children with Guillain-Barre Syndrome in Sari Bou-Ali Sina Hospital
Background and purpose: Guillain-Barre syndrome (GBS) is an autoimmune disorder that has different clinical and pathologic findings. Its diagnosis is based on clinical findings. This study aimed at investigating the characteristics of the disease in a region in north of Iran. Materials and methods: In this descriptive-analytical study, the records (2008-2018) of children under the age of 15 ye...
متن کامل