Primary amyloidosis iwith plasmacytic dyscrasia and a tetramer of Bence Jones type lambda globulin in the serum and urine.

An abnormal protein has been isolated ported occurrence of a urinary Bence from both the serum and urine of a paJones tetramer. The sedimentation coeftient with generalized amyloidosis and ficient of the protein was 5.OS, and its plasmacytic dyscrasia. Immunological molecular weight 79,000. Reduction and and biochemical techniques were used to alkylation, electrophoresis, and ultracendemonstrate that the proteins isolated trifugation showed it to consist of four from each source were identical and were monomers covalently bonded to form a tetramer of a lambda-type Bence Jones two dimers, which were in turn noncoglobulin. This appears to be the first revalently bonded to form the tetramer.