Pd-catalyzed enantioselective intramolecular α-arylation of α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles.
نویسندگان
چکیده
Catalytic synthesis of chiral spirocyclic ketones was accomplished via the Pd-catalyzed intramolecular α-arylation of α-substituted cyclic ketones. The obtained spirocyclic ketone could be converted into a bifunctional organocatalyst.
منابع مشابه
Synthesis of C₂-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides.
A series of C₂-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities.
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Chem. Commun., 2015, 51, 8385 | 8385 Cite this:Chem. Commun., 2015, 51, 8385 Correction: A new chiral C1-symmetric NHC-catalyzed addition to a-aryl substituted a,b-disubstituted enals: enantioselective synthesis of fully functionalized dihydropyranones Hong Lu, Jin-Yu Liu, Chen-Guang Li, Jun-Bing Lin, Yong-Min Liang and Peng-Fei Xu* Correction for ‘A new chiral C1-symmetric NHC-catalyzed additi...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 17 شماره
صفحات -
تاریخ انتشار 2015