Genetic risk factors for respiratory diseases of preterm infants
نویسندگان
چکیده
Aims Genetic variants of pulmonary surface glycoproteins like Muc5a and Muc5b are known to affect mucociliary clearance, control of infections and maybe associated with pulmonary fibrosis [1-3]. We tested the hypothesis that Muc5b (rs35705950) is associated with bronchopulmonary dysplasia (BPD) in mechanically ventilated preterm infants. In addition, we aimed to identify common variants associated with the need for surfactant treatment.
منابع مشابه
Effective Factors of INSURE Method Failure in Treatment of Respiratory Distress Syndrome in Preterm Infants
Background INtubate-SURfactant-Extubate (INSURE) method is one of the effective methods in treatment of infants with respiratory distress syndrome (RDS). This study was performed to predict risk factors for the failure of INSURE method in treatment of RDS in preterm infants. Materials and Methods: In this cross-sectional study, 192 infants who born between July 2011 and April 2016 at women and...
متن کاملRespiratory symptoms in preterm infants: burden of disease in the first year of life
OBJECTIVE While respiratory symptoms in the first year of life are relatively well described for term infants, data for preterm infants are scarce. We aimed to describe the burden of respiratory disease in a group of preterm infants with and without bronchopulmonary dysplasia (BPD) and to assess the association of respiratory symptoms with perinatal, genetic and environmental risk factors. ME...
متن کاملCould mean platelet volume predict developing of bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome?
Introduction: some studies have suggested correlation between MPV index and inflammatory diseases such as rheumatoid arthritis in adults. Though bronchopulmonary dysplasia is also an inflammatory disease which develops in preterm neonates with Respiratory distress syndrome, we decided to study the possible correlation between the mean platelet volume (MPV) and the occurrence of bronchopulmonary...
متن کاملComparison of risk factors between preterm and term infants hospitalized for severe respiratory syncytial virus in the Russian Federation
BACKGROUND Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in infants. Preterm birth, in addition to several demographic and environmental factors, increases the risk for development of severe RSV infection. The purpose of this study was to describe differences in risk factors and protective factors between preterm birth (up to 35 weeks' gestational age...
متن کاملبررسی تأثیر جنتامایسین خوراکی در پیشگیری از آنتروکولیت نکروزان در نوزادان نارس
ABSTRACT Necrotizing enterocolitis is the most common acquired life threating intestinal disease in the neonates. This disease affects predominately preterm infants (less than 37 weeks gestational age). The pathogenesis of NEC is unknown predisposing. Risk factors for NEC include: lschemia, Hypotension, RDS (Respiratory distress syndrom), umbilical artery catheterization, Hypothermia...
متن کامل