Chapter 7 Pain , not chronic disease , is associated with the recurrence of depressive and anxiety disorders

نویسندگان

  • Patricia van Oppen
  • Stephanie S. Leone
  • Harm W.J. van Marwijk
  • Henriëtte E. van der Horst
  • Brenda W.J.H. Penninx
چکیده

Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders ABSTRACT Objective To determine whether specific chronic diseases and pain characteristics are associated with depression and anxiety recurrence and to examine whether these associations were mediated by subthreshold depressive or anxiety symptoms. Method 1,122 individuals with remitted depressive or anxiety disorder (Netherlands Study of Depression and Anxiety) were followed up till four years. The impact of specific chronic diseases and pain characteristics on recurrence was assessed using Cox regression and mediation analyses. Results Chronic diseases were not associated with recurrence. pain severity (HR 1.18, p=.01) were associated with an increased hazard of depression recurrence but not anxiety. Subthreshold depressive symptoms largely mediated the associations between pain and depression recurrence. Conclusion Pain, not chronic disease, increases the likelihood of depression recurrence, largely through its association with increased subthreshold depressive symptoms. These findings support the idea of a reinforcing mechanism between pain and depression and stress the importance of elucidating the neurobiological links to optimize pain and depression management.

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تاریخ انتشار 2013