Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures.
نویسندگان
چکیده
HeLa cells in culture synthesize metallothionein. To investigate the effects of glucocorticoids on metallothionein synthesis we adapted HeLa cells to growth in a defined medium lacking hydrocortisone. In this defined medium, containing 1.5 x 10(-6)M Zn2+, dexamethasone (10(-6)M) caused a five- to sixfold increase in the synthesis of metallothionein. Progesterone (10(-5)M), a known antagonist of glucocorticoids, inhibited this response by 50 percent.
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ورودعنوان ژورنال:
- Science
دوره 204 4389 شماره
صفحات -
تاریخ انتشار 1979