Target organ toxicity: endocrine system. May 20-21, 1980, Morgantown, West Virginia.

THE AUGMENTATION of the action of some cytotoxic drugs, as well as x-rays, by antibody directed against the surface of the target cell has been reported (Davies, Buckham and Manstone, 1974; Ghose and Cerini, 1969; Rubens and Dulbecco, 1974) and reviewed (Rubens, 1974). The augmentation effect is of potential interest in chemotherapy since it may be possible to increase the specificity of anticancer agents. However, the mechanism of this augmentation by antibody is still not understood. In this article, we report on experiments in which the spectrum of potentiation has been explored further, using the same in vitro system as in a previous study (Rubens and Dulbecco, 1974). In this way it was possible to compare the augmentation of different agents under similar conditions.