Effects of angiotensin II and captopril on rewarding propreties of morphine
نویسندگان
چکیده
The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine selfadministration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between preand post-conditioning compared to morphine group. In selfadministration experiment number of active lever pressing was significantly greater than passive in morphine group. In captopril group number of active lever pressing was significantly lower than morphine group however, there was not significant difference between active and passive lever pressed number. The results showed that captopril significantly decreased morphine-induced conditional place preference and morphine self-administration but the effect of Ang II was not significant. It can be concluded that RAS may have a role in rewarding properties of morphine.
منابع مشابه
The Effects of Angiotensin II and Captopril on Expression of Morphine Withdrawal Signs in Rat
The mechanisms of drug dependence and rewarding properties of opiates are not exactly known and several neurotransmitters seem to be involved. It is possible that the rennin-angiotensin system could interact with the opioid system, since it has been shown that angiotensin II(Ang) and ACE inhibitors have analgesic, anticonvulsant and antidepression effects and in some cases they could antagonize...
متن کاملThe Effects of Angiotensin II and Captopril on Expression of Morphine Withdrawal Signs in Rat
The mechanisms of drug dependence and rewarding properties of opiates are not exactly known and several neurotransmitters seem to be involved. It is possible that the rennin-angiotensin system could interact with the opioid system, since it has been shown that angiotensin II(Ang) and ACE inhibitors have analgesic, anticonvulsant and antidepression effects and in some cases they could antagonize...
متن کاملEffects of angiotensin II and captopril on rewarding properties of morphine.
The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine self-administration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of...
متن کاملEffects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats.
The dopaminergic mesolimbic system is considered to be crucial in rewarding actions of opiates. Recent studies have suggested probable interaction between the renin-angiotensin and mesolimbic dopaminergic systems. The present study was undertaken to investigate the effects of Ang II and captopril injection into VTA on morphine self-administration. Male Wistar rats were initially trained to rece...
متن کاملEffects of microinjection of angiotensin II and captopril into nucleus accumbens on morphine self-administration in rats.
With an aim to investigate the effects of injection of angiotensin II (Ang II) and captopril into the nucleus accumbens (NAC) on morphine self-administration, male Wistar rats were first trained to receive small pellets of food by pressing the active lever in self-administration apparatus. The animals, divided into 4 groups (saline, morphine, captopril and Ang II) were placed in self-administra...
متن کامل