Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.
نویسندگان
چکیده
PERSPECTIVES AND SUMMARY ............................... .... ....................................... 224 UPTAKE OF LIPOPROTEIN-BOUND CHOLESTEROL BY MACROPHAGES ................................................................................................ 226 Receptor for Acetyl-LDL .......................................................................................... 227 Receptor for LDLIDextran Sulfate Complexes ...................................................... 235 Receptor for f3-VLDL ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,.,,,,,,,,.,,,,.,,.", ... ,,,, .... ,, ............. ,,.............. 237 Receptors for Cholesteryl Ester/Protein Complexes from Atherosclerotic Plaques .............................................................. ,................... 241 PROCESSING AND STORAGE OF LIPOPROTEIN-BOUND CHOLESTEROL BY MACROPHAGES ............................... . ................................................ 243 Endocytosis and Lysosomal Hydrolysis .................................................................... 243 Cytoplasmic Re-esterification and Hydrolysis of Lipoprotein-Derived Cholesteryl Esters ........................................................................ "."." . . . . . . . . . . .. . . . . . ".".. 244 The Cho{estery{ Ester Cycle " ... " ... " .... " ....... " .. "....................................................... 247 SECRETION OF CHOLESTEROL AND APOPROTEIN E BY MACROPHAGES ........................................................................................ 249 Cholesterol Excretion Dependent on Cholesterol Acceptors .................................... 249 Synthesis and Secretion of Apoprotein E in Response to Cholesterol Loading , .. "", 252 IMPLICATIONS FOR FOAM CELL FORMATION IN ATHEROSCLEROSIS . . . . . . . . . . . . . . . . . ...... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..... . . . . . . . . . . . . . . . 255 The Foam Cell in Familial Hypercholesterolemia .................................................. 257
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ورودعنوان ژورنال:
- Annual review of biochemistry
دوره 52 شماره
صفحات -
تاریخ انتشار 1983