Supplemental Methods
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چکیده
The International Headache Genetics Consortium (IHGC) study collected 23 285 cases with migraine and 95 425 controls from 29 studies for a meta-analysis of genome-wide association data. For a subset of the cohorts sufficiently detailed phenotype information was available to allow subclassification into either of the two migraine subtypes, migraine with aura (5 118 cases versus 74 239 controls) or migraine without aura (7 107 cases versus 69 427 controls). The CARDIoGRAM study combined data from 14 GWAS studies of CAD for a total of 22 233 cases versus 64 762 controls. Three study cohorts were part of both the IHGC and CARDIoGRAM studies (deCODE, 1958 Birth Cohort and KORA). To assure independence between the migraine and CAD datasets we reperformed the IHGC migraine meta-analysis without deCODE and 1958 Birth Cohort, and the CARDIoGRAM CAD meta-analysis without GERMIFS III (KORA), resulting in two datasets without overlapping samples (19 981 migraine cases versus 56 667 controls, and 21 076 CAD cases versus 63 014 controls). Descriptions of the included cohorts, and criteria for diagnosing migraine or CAD in each study, are given in Tables e1 and e2. In addition to using summary statistics (P value, effect allele, effect size for SNPs) from these studies, we also used individual-level genotype data from the six migraine cohorts where such data were available: German MA (997 cases, 1105 controls), German MO (1208 cases, 2564 controls), LUMINA MA (820 cases, 4774 controls), LUMINA MO (1118 cases, 2016 controls), Finnish MA (1032 cases, 3513 controls) and the HUNT Study, Norway (MO cases only; 1175 cases, 1097 controls).
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