Clinical studies of induction agents. XXXIX: CT1341, a new steroid anaesthetic.

CT1341 is a new intravenous anaesthetic which appears to have overcome the disadvantages of the earlier steroid. The formulation is a mixture of two closely related steroids with Cremophor EL and the optimum dose for induction is 50-60 (J/kg though much larger doses can be given without serious side effects. As the dose is increased the incidence of muscle movements, respiratory depression and hypotension rises. Duration of action is intermediate between that of the barbiturates and propanidid and postoperative sickness is rare.