The Antigenic Potency of Epidemic Influenza Virus following Inactivation by Ultraviolet Radiation

Optimizing the process of inactivating influenza virus subtype H9N2 by formalin in the production of killed avian influenza vaccine

Avian influenza is one of the most important diseases in avian industry, which also threats human population. Thus, vaccination is necessary for controlling this viral disease. In this study, killed vaccine of avian influenza subtype H9N2 and formalin solution (for virus inactivation) were used. It is necessary to study the effect of different factors such as formalin concentration, as well as ...

The Preparation and Properties of Influenza Virus Vaccines Concentrated and Purified by Differential Centrifugation

Influenza virus vaccines containing from 1 to 10 mg. of virus materials per cc. concentrated and purified from infectious allantoic fluids by means of one or two cycles of differential centrifugation and inactivated by different treatments have been prepared and subjected to laboratory tests. Suitable inactivation of the virus preparations with retention of full red cell agglutinating activity ...

تغییرات ژنتیکی ویروس و فرار از سامانه ایمنی، چالش‌های پیش‌رو علیه آنفلوآنزا: مقاله مروری

The spread of influenza viruses in multiple bird and mammalian species is a worldwide serious threat to human and animal populations' health and raise major concern for ongoing pandemic in humans. Direct transmission of the avian viruses which have sialic acid specific receptors similar to human influenza viruses are a warning to the emergence of a new mutant strain that is likely to share mole...

Construction of chimeric protein 3M2e.FliC and its immunoinformatics analyses and expression in Bacillus subtilis

Introduction: Influenza A virus causes unpredictable epidemics and pandemics by creating antigenic variations. With the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. Hence, designing an applicable and cross protective strategy to counter this virus is of great importance. To achieve this, choosing conserved antigenic regions in influenza virus...

Antigenic variation between rabies virus strains and its relevance in vaccine production and potency testing