Atypical Protein Kinase C ζ Exhibits a Proapoptotic Function in Ovarian Cancer
نویسندگان
چکیده
Authors' A Hospital, C 3Division University, Note: Sup Cancer Res Correspon ogy, Instit Platz 1, Eg Fax: 49-72
منابع مشابه
GnRH-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells via activation of stress-induced MAPKs p38 and JNK and proapoptotic protein Bax.
Recently, we could show that gonadotropin-releasing hormone (GnRH)-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells in vitro and in vivo. In the present study, we have ascertained receptor binding and effects of GnRH-II antagonists on mitogenic signal transduction and on activation of proapoptotic protein Bax. The GnRH-II antagonists tested showed EC50 valu...
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