Hydroxy Propyl-Beta-Cyclodextrin Summary for IND / IRB Submissions
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چکیده
Cyclodextrins are non-reducing cyclic glucose oligosaccharides resulting from the cyclomaltodextrin glucanotransferase (E.C. 2.4.1.19; CGTase) catalyzed degradation of starch. Their structures have been reviewed. There are three common cyclodextrins with 6, 7 or 8 D-glucopyranonsyl residues (α-, β-, and γ-cyclodextrin respectively) linked by α-1,4 glycosidic bonds. The glucose residues have the 4 C1 (chair) conformation. All three cyclodextrins have similar structures (that is, bond lengths and orientations) apart from the structural necessities of accommodating a different number of glucose residues.
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