NSAID Induction of p75 in the Prostate: A Suppressor of Growth and Cell Migration Via the p38 MAPK Pathway
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منابع مشابه
Signaling and Regulation NSAID Inhibition of Prostate Cancer Cell Migration Is Mediated by Nag-1 Induction via the p38 MAPK-p75 Pathway
The nonsteroidal anti-inflammatory drugs (NSAID) R-flurbiprofen and ibuprofen have been shown to induce expression of p75 (neurotrophin receptor) in prostate cancer cell lines. p75, a tumor necrosis factor receptor superfamily member, is a proapoptotic protein that functions as a tumor suppressor in the human prostate. Expression of p75 is lost as prostate cancer progresses and is minimal in se...
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The p75 neurotrophin receptor (p75(NTR)) functions as a tumor suppressor in prostate epithelial cells, where its expression declines with progression to malignant cancer. Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75(NTR) expression in several prostate cancer cell lines leading to p75(NTR)-mediated decreased survival. Using the 2-phenyl propionic acid moiety ...
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The p75 neurotrophin receptor (p75) functions as a tumor suppressor in prostate epithelial cells, where its expression declines with progression to malignant cancer. Previously, we showed that treatment with R-flurbiprofen or ibuprofen induced p75 expression in several prostate cancer cell lines leading to p75-mediated decreased survival. Using the 2-phenyl propionic acid moiety of these profen...
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