ALKERAN TABLETS NAME OF THE DRUG: Alkeran tablets contain 2mg melphalan. Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional
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چکیده
Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent that is active against selected human neoplastic diseases. The chemical name for melphalan, is 4-bis (2-chloroethyl) amino-L-phenylalanine, it has a molecular weight of 305.20, and its molecular formula is C13H18Cl2N2O2, CAS No.: 148-82-3 and the chemical structure is:
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The Effect of an Amino Acid-lowering Diet on the Rate of Melphalan Entry into Brain and Xenotransplanted Glioma1
Melphalan (i.-phenylalanine mustard, L-PAM, alkeran; molecular weight, 305,000) is transported across tumor cell membranes and the blood-brain barrier by the large neutral amino acid (LNÕA) transport system. Normally, plasma LNAA levels are high enough and the affin ity low enough that this system does not transport much melphalan into the brain. However, plasma amino acids can be reduced by f...
متن کاملMelphalan Entry into Brain and Xenotransplanted Glioma The Effect of an Amino Acid-lowering Diet on the Rate of Updated Version
Melphalan (i.-phenylalanine mustard, L-PAM, alkeran; molecular weight, 305,000) is transported across tumor cell membranes and the blood-brain barrier by the large neutral amino acid (LNÕA) transport system. Normally, plasma LNAA levels are high enough and the affin ity low enough that this system does not transport much melphalan into the brain. However, plasma amino acids can be reduced by f...
متن کاملSpecificity of isozymes of murine hepatic glutathione S-transferase for the conjugation of glutathione with L-phenylalanine mustard.
Glutathione S-transferase (GST) isozymes play a central role in the protection of cells from cytotoxic chemicals and have a putative role in the intrinsic and acquired resistance of tumors to cytotoxic drugs. We have isolated and purified GST isozymes from mouse liver (M. Warholm et al., Biochemistry, 25: 4119-4125, 1986) and analyzed the metabolic products of the reaction of L-phenylalanine mu...
متن کاملL-phenylalanine mustard (melphalan) uptake and cross-linking in the RPMI 6410 human lymphoblastoid cell line.
L-Phenylalanine mustard (melphalan) induced a time- and concentration-dependent arrest of cycling RPMI 6410 cells in the G2 phase of the cell cycle as evidenced by flow cytofluorometry. A melphalan exposure of 1 microgram/ml for 1 hr caused a temporary G2 blockage which was overcome by 48 hr. Higher concentrations or longer exposures lead to irreversible blockages. Melphalan caused DNA cross-li...
متن کاملThe role of hyperthermia in regional alkylating agent chemotherapy.
The role of hyperthermia during regional alkylating agent chemotherapy is controversial. The aim of this study was to determine the exact contribution of hyperthermia to tumor response during isolated limb infusion with l-phenylalanine mustard. Rats bearing rodent fibrosarcoma on the hindlimb underwent isolated limb infusion with saline, saline plus heat, l-phenylalanine mustard, l-phenylalanin...
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