The role of ANGPTL3 in controlling lipoprotein metabolism
نویسندگان
چکیده
Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids. ANGPTL3-deficiency due to loss-of-function mutations in the ANGPTL3 gene causes familial combined hypobetalipoproteinemia (FHBL2, OMIM # 605019), a phenotype characterized by low concentration of all major lipoprotein classes in circulation. ANGPTL3 is therefore a potential therapeutic target to treat combined hyperlipidemia, a major risk factor for atherosclerotic coronary heart disease. This review focuses on the mechanisms behind ANGPTL3-deficiency induced FHBL2.
منابع مشابه
Association of angiopoietin-like protein3 (ANGPTL3) with HTGL and LPL activities in human plasma
Background: The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins and HDL. Methods: Angiopoietin-like protein-3 (ANGPTL3), LPL activity, HTGL activity, remnant lipoproteins (RLP-C & RLP-TG), small dense LDL-Cholesterol (sd LDL...
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