The structure of pepstatin.

نویسندگان

  • H Morishima
  • T Takita
  • T Aoyagi
  • T Takeuchi
  • H Umezawa
چکیده

The UV spectrum of pepstatin shows only end absorption. Strong absorptions centered at 1630cm"1 and 1540cm"1 in the infrared spectrum suggest that pepstatin is a kind of peptide. Pepstatin shows a negative reaction for ninhydrin, but positive for RydonSmith reagent. Pepstatin has no free basic function. It gives mono-methyl ester by treatment of diazomethane. The di-acetyl derivative of the methyl ester is obtained by acetic anhydride and pyridine. Acid hydrolysis of pepstatin in 6 N hydrochloric acid at 110°C for 27 hours gave two ninhydrin-positive products and another ma-

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 23 5  شماره 

صفحات  -

تاریخ انتشار 1970