Aqueous Outflow Facility in Monkeys and the Effect of Topical Corticoids.

T.opically applied corticoids were shown to produce in man an increase in intraocular pressure, a reduction in outflow facility,' 2> G and dilatation of the pupil. In addition, important differences in this respect were depicted between the normal and glaucomatous eye.' These findings suggested an extensive search for a suitable laboratory animal in which these effects may be reproduced and their mechanism definitively investigated. This presentation will be limited to studies of the effect of topically applied dexamethasone 21-phosphate, 0.1 per cent (Decadron, Merck Sharp & Dohme), and subjunctivally administered methylprednisolone acetate (Depo-Medrol, Upjohn) in three monkey species: Macaca mulatto,