Is Rifampin necessary for the treatment of Rhodococcus equi infections in Foals?
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چکیده
Rifampin is a broad-spectrum, concentration-dependent, bactericidal and/or bacteriostatic antibiotic, with activity against many gram-positive and some gram-negative aerobic bacteria as well as facultative anaerobic organisms (Wilson et al., 1988). It is a complex macrocyclic semisynthetic antibiotic derived from rifamycin B. The principle use of rifampin in equine medicine is for combination treatments against Rhodococcus equi infections in foals (Plumb, 2011). It can also be used to treat proliferative enteropathy caused by Lawsonia intracellularis in foals. However, rifampin is not specifically approved for veterinary use. In Europe, rifampicin is listed by Federation of Veterinarians of Europe (FVE) on the essential substance list for horses (Commission Regulation (EC) No 1950/2006).
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Resistance studies of erythromycin and rifampin for Rhodococcus equi over a 10-year period
This study sought to determine whether an increase in resistance of Rhodococcus equi to the antibiotics rifampin and erythromycin occurred over a 10-year period. This was carried out by the use of E test strips for rifampin and erythromycin to determine the MIC (minimum inhibitory concentration) values of Rhodococcus equi to this combination of antibiotics.The findings of this study indicated t...
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Macrolide and rifampin resistance developed on a horse breeding farm after widespread use was instituted for treatment of subclinical pulmonary lesions in foals. Resistance occurred in 6 (24%) of 25 pretreatment and 8 (62%) of 13 (62%) posttreatment isolates from affected foals. Drug-resistant isolates formed 2 distinct genotypic clusters.
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متن کاملDiagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals.
Rhodococcus equi, a gram-positive facultative intracellular pathogen, is one of the most common causes of pneumonia in foals. Although R. equi can be cultured from the environment of virtually all horse farms, the clinical disease in foals is endemic at some farms, sporadic at others, and unrecognized at many. On farms where the disease is endemic, costs associated with morbidity and mortality ...
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