The entorhinal map of space.

نویسنده

  • Kei M Igarashi
چکیده

How do we know where we are, and how do we remember the places we visited? Since the discovery of place cells in 1971, our understanding of the brain's maps of external space has exploded. Yet the origin of the place-cell signal remained elusive. The discovery of grid cells in the medial entorhinal cortex (MEC) in 2005 put place cells in a context, since the existence of grid cells pointed to circuit mechanisms that might explain the formation of place cells. In this review, I shall review recent experimental and theoretical advances in the understanding of how space is mapped in the medial entorhinal cortex. I will also review recent studies of interactions between hippocampus and the lateral entorhinal cortex (LEC). Research on spatial mapping in the hippocampal-entorhinal system provides a fundament for future attempts to decipher some of the neural-circuit codes of the cortex.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A map of abstract relational knowledge in the human hippocampal–entorhinal cortex

The hippocampal-entorhinal system encodes a map of space that guides spatial navigation. Goal-directed behaviour outside of spatial navigation similarly requires a representation of abstract forms of relational knowledge. This information relies on the same neural system, but it is not known whether the organisational principles governing continuous maps may extend to the implicit encoding of d...

متن کامل

Spatial Representation: Maps of Fragmented Space

Grid cells in medial entorhinal cortex are thought to act as a neural metric for spatial navigation. A new study has examined the ability of grid cells to use self-motion cues to form a global map across fragmented spaces.

متن کامل

The effect of intraperitoneal injection of N6-cyclohexyladenosine, a selective adenosine A1 receptor agonist, on entorhinal cortex-kindled seizures in rats

The effects of intraperitoneal injection of N6-cyclohexyladenosine (CHA, a selective adenosine A1 receptor agonist) and 8-cyclopenthyle-I-3-dimethylexanthine (CPT, a selective adenosine A1 receptor antagonist) on entorhinal cortex-kindled seizures were investigated. Fully entorhinal cortex-kindled rats received normal saline (control), CHA (0.06, 0.12 and 0.25 mg/kg) or CPT (0.06 and 0.12 mg/kg...

متن کامل

A Note on Quadratic Maps for Hilbert Space Operators

In this paper, we introduce the notion of sesquilinear map on Β(H) . Based on this notion, we define the quadratic map, which is the generalization of positive linear map. With the help of this concept, we prove several well-known equality and inequality...  

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Brain research

دوره 1637  شماره 

صفحات  -

تاریخ انتشار 2016