O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence.

نویسندگان

  • Shannon Weiman
  • Satoshi Uchiyama
  • Feng-Ying C Lin
  • Donald Chaffin
  • Ajit Varki
  • Victor Nizet
  • Amanda L Lewis
چکیده

GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.

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منابع مشابه

Discovery and characterization of sialic acid O-acetylation in group B Streptococcus.

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عنوان ژورنال:
  • The Biochemical journal

دوره 428 2  شماره 

صفحات  -

تاریخ انتشار 2010