Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity
نویسندگان
چکیده
The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor gammat, lymphotoxin (LT) alpha1beta2-LTbetaR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.
منابع مشابه
Innate lymphoid cells in immunity and disease.
The family of innate lymphoid cells (ILCs) comprises of natural killer (NK) cells, Rorγt-dependent ILCs (lymphoid tissue inducer (LTi) cells, ILC22, and ILC17), and type 2 ILCs. Apart from a common requirement for inhibitor of DNA binding 2 (Id2) expression and common γ-chain (γc) signaling, the differentiation of ILC populations is regulated by distinct transcription factors. ILCs play fundame...
متن کاملRunx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages.
Hematopoietic lymphoid tissue inducer (LTi) cells are essential for the development of secondary lymphoid tissues including lymph nodes and Peyer's patches. Two transcription factors, the helix-loop-helix inhibitor Id2 and the retinoic acid-related orphan receptor γt (Rorγt), have been shown to be crucial for LTi cell development. However, it remains unclear how the specification of multipotent...
متن کاملA novel mucosal RORγt+NKp46+ cell subset is a source of interleukin-22
Lymphoid tissue-inducer cells are hematopoietic cells essential for the organogenesis of several lymphoid structures during both fetal and adult life, whereas natural killer cells are key effector lymphocytes of the innate immune system. A series of recent reports has identified RORγt(+)NKp46(+) interleukin-22-producing cells in gut and tonsils that share features with both lymphoid tissue-indu...
متن کاملNotch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
Lymphoid tissue development is initiated during embryogenesis by the migration of lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the formation of lymph nodes and Peyer's patches. In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression ...
متن کامل1 LT β R - independent development of intestinal IL - 22 - producing NKp 46 + innate lymphoid cells
The natural cytotoxicity receptor NKp46 (encoded by Ncr1) is an activating receptor expressed by innate lymphoid cells (ILC), including NK cells, a subset of γδ T cells and intestinal RORγt IL-22 cells (NCR22 cells). Previous studies have proposed a critical role for NCR22 cells in mucosal barrier function through IL-22-mediated production of anti-bacterial peptides from intestinal epithelial c...
متن کامل