Antenatal MRI in the diagnosis of tuberous sclerosis.

Tuberous sclerosis (TS) is an autosomal dominant neurocutaneous syndrome characterized by multiorgan hamartomas, epilepsy and mental retardation. Prenatal genetic testing for a mutation is laborious, time consuming and not widely available because of the genetic heterogeneity, polymorphism and a high rate of denovo mutations(1,2). We hereby highlight the utility of prenatal magnetic resonance imaging (MRI) as an adjunctive imaging modality in the diagnosis and prognosis of TS.