Preparation and in Vitro Evaluation of Repaglinide Tablets

The purpose of this article was to prepare and optimize the ingredients of Repaglinide tablets. The impacts of ingredients (diluents, disintegrants and lubricants) content on tablets were evaluated. The optimum prescription contained Repaglinide, meglumine, poloxamer, MCC, maize starch, PVPP, magnesium stearate and appropriate PVP K30.The tablets were evaluated by Carr’s index, hardness, friability and dissolution study. The dissolution of self-made tablets were compared with that of the commercial brand Novo Norm in 4 dissolution media: 0.1mol/L HCL, citrate buffer at pH values of 5.0, phosphate buffer at pH values of 6.8 and distilled water. The dissolution samples were assayed using a HPLC method. The dissolution results were analyzed by similarity factors (f2). The results shows optimum tablets had similar dissolution profiles with the commercial brand.