The Statistical Simplex Method for Experimental Design in Process Optimization
نویسنده
چکیده
Finding optimal operating conditions fast for process systems is a key competitive factor in fine chemicals and pharmaceutical industrial sectors to increase the value added in many stages of a product/process lifecycle. To deal successfully with noise and bias in experimental optimization a statistical characterization of a local optimum that is more amenable for process outputs rather than numbers is discussed. The Kendall’s statistic τ is used for characterizing candidate local optima as clusters of strongly correlated points. A statistical simplex algorithm that resorts to correlation-based ordering of the simplex vertices is proposed. Results obtained in the optimization of the operating policy for a semi-batch reactor are presented.
منابع مشابه
Development and Optimization of Ferrous Fumarate Chewable Tablets by Simplex Experimental Design
Chewable ferrous fumarate tablet is the best iron dosage form for children due to better compliance and lower teeth staining compared to the oral drop. Because of the different desirable properties of chewable tablets and the opposing effects of fillers on them, the mathematical experimental design was used as the formulation approach. Different series of formulations based on single filler (La...
متن کاملSimplex design method in simultaneous spectrophotometric determination of silicate and phosphate in boiler water of power plant and sewage sample by partial least squares
Partial least squares modeling as a powerful multivariate statistical tool was applied tothe simultaneous spectrophotometric determination of silicate and phosphate in aqueoussolutions. The concentration range for silicate and phosphate were 0.02-0.6 and 0.4-3 μg ml-1,respectively. The experimental calibration set was composed with 30 sample solutions using amixture design for two component mix...
متن کاملOptimization of Experimental Conditions for Fabrication of Carbon Nanotubes Based onTaguchi obust Design Method
Carbon nanotube, a new structure of carbon element, is composed of graphene sheets rolled into closed concentric cylinders with diameter of the order of nanometers and length of micrometers. Liquid arc discharge was used for fabrication of carbon nanotubes, and subsequently a modified acid treatment method applied for purification stage. A statistical design of experimental (DOE) (Taguchi metho...
متن کاملThe Statistical Simplex Method for Experimental Optimization with Process Data
Experimental optimization with scarce and noisy process data is a key issue in laboratory automation for faster chemical process research and development, real-time process optimization, extremum-seeking control systems and self-calibrating instruments. To deal successfully with noise and uncontrollable factors in experimental design for process optimization a statistical characterization of a ...
متن کاملFixture Design and Work Piece Deformation Optimization Using the Iterative Simplex Algorithm
Presents article is deal with optimization of the fixture for end milling process, the most important objective being the minimization of work piece deformation by changing the layout of fixture elements and the clamping forces. The main objective of this work has been the optimization of the fixtures Work piece deformation subjected to clamping forces for End milling operation. The present ana...
متن کامل