In vivo Models for Candida Albicans Biofilms Study

The incidence of invasive fungal infections has increased significantly in the last several years, which can be explained by the widely using of wide-spectrum antibiotics and immunosuppressant, invasive procedures and medical implant devices. Among the fungal pathogens of humans, Candida represented by Candida albicans, is one of the species that are the most frequently associated with biofilm infection, particularly which on medical implants, and this has a significant impact on morbidity and mortalit [1]. invasive procedures and medical implant devices C. albicans which can cause both superficial and systemic infections, is one of the main pathogenic microorganisms caused nosocomial infection. Data in 2002 from the US National Nosocomial Infections Surveillance System ranked C. albicans as the fourth most common cause of bloodstream infection, behind coagulaseIn vivo Models for Candida Albicans Biofilms Study Wenrui Gu1, Dongmei Xu2, Dongmei Guo3, Liuping Zhang4 and Shujuan Sun5* 1School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong Province, People’s Republic of China 2Department of Nephrology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, 250014, P.R. China 3Department of Out-Patient, Qianfoshan Hospital Affiliated to Shandong University, Jinan, 250014, P.R. China 4School of Pharmaceutical Sciences, Taishan Medical University, Taian, 271016, Shandong Province, People’s Republic of China; 5Department of Pharmacy, Qianfoshan Hospital Affiliated to Shandong University, Jinan, 250014, Shandong Province, People’s Republic of China.