Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview
نویسندگان
چکیده
Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior.
منابع مشابه
Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis.
OBJECTIVE To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia. DESIGN Systematic overview and meta-regression analyses of randomised controlled trials, as a basis for formal development of guidelines. SUBJECTS 12 649 patients in 52 randomised trials comparing atypical antipsychotics (amisulpride, clozapine, olanzapine, quetia...
متن کاملAtypical antipsychotics in the treatment of schizophrenia.
Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symptoms as well as treatment-refractory patients. The most important side effects...
متن کاملمقایسه مصرف آنتیسایکوتیکهای تیپیک و آتیپیک در ایجاد علایم وسواسی بیماران مبتلا به اسکیزوفرنیا
AbstractObjectives: The effects of typical and atypical antipsychotics on inducing obsessive-compulsive symptoms in patients with schizophrenia were compared in this study. Method: In a comparative-descriptive study 64 patients with schizophrenia (32 patients in typical antipsychotic group and 32 patients in atypical antipsychotic group) were investigated. All patients with a confirmed diagnosi...
متن کاملA Review of Metabolic Issues in Atypical Antipsychotic Treatment
Reports of diabetes, diabetic ketoacidosis, hyperglycemia, and dyslipidemias in patients treated with atypical antipsychotics have increased in recent years. This increase has led to growing concern about a possible link between these metabolic effects and atypical antipsychotic therapy. This review article provides an overview of the evidence for an association between glucose and lipid dysreg...
متن کاملAtypical antipsychotics do not reverse prepulse inhibition deficits in acutely psychotic schizophrenia.
OBJECTIVES To investigate the effects of atypical antipsychotics on prepulse inhibition, startle response and habituation in acutely psychotic patients with schizophrenia, and investigate whether prepulse inhibition deficit improvements are a result of the direct impact of atypical antipsychotics or improvements in antipsychotic-related symptoms. METHODS Prepulse inhibition, habituation and ...
متن کامل