A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy.
نویسندگان
چکیده
A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and synergistic chemotherapy-photodynamic therapy (PDT), targeted tumor imaging and therapy. The sophisticated copolymer designed in this work can load the PDT photosensitizer (ZnPc) and chemotherapy drug (DOX) simultaneously, which exhibits an excellent performance in chemotherapy-PDT targeted cancer and tumor therapy for both in vitro studies performed with HepG2 cells and in vivo tests with mice. This work provides a new drug formulation with a chemotherapy-PDT synergistic effect by virtue of the supramolecular material design, which possesses the advantages of an ultra-low drug dosage and highly-efficient in vivo targeted tumor imaging/therapy.
منابع مشابه
A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy† †Electronic supplementary information (ESI) available: NMR spectra, ITC, UV-vis spectra, zeta potential, TEM and additional characterization data. See DOI: 10.1039/c5sc00994d Click here for additional data file.
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ورودعنوان ژورنال:
- Chemical science
دوره 6 10 شماره
صفحات -
تاریخ انتشار 2015