Efficacy And Tolerability Of Transdermal Phenobarbital For Seizure Control In Cats Principal Investigator

Reliable administration of anti-seizure drugs, like phenobarbital, is critical to maintain seizure control in cats. Unfortunately administering oral phenobarbital to cats can be difficult, resulting in inconsistent dosing, stress to the cat and injury to the owner. Furthermore, a missed dose of anti-seizure medications can result in a seizure. The purpose of this study is to compare blood levels achieved using topical phenobarbital to levels achieved using oral phenobarbital in cats with seizures. Additionally, we will compare side effects and ease of administration between oral and topical administration of phenobarbital. Cats will receive oral medication for three months, followed by topical phenobarbital for three months. Our hypothesis is that topical phenobarbital will achieve comparable serum levels to oral phenobarbital, owners will be more satisfied with the topical administration, and that side effects will be minimal and similar to known side effects of phenobarbital. The Role Of Urothelial Glycosaminoglycans In The Development Of Canine Recurrent Urinary Tract Infections Principal Investigators Sara Colopy, Department of Surgical Sciences Michael Wood, Department of Medical Sciences Abstract Recurrent urinary tract infections (UTI) are common in dogs and are associated with poor quality of life due to frequent and painful urination. Repeated courses of antibiotics lead to development of drug-resistant infections. Treatments targeted at preventing UTI would be ideal to avoid the poor quality of life and drug resistance associated with recurrent infections. Glycosaminoglycans (GAGs) lining the bladder surface have been shown to be important in maintaining a tight barrier to bacteria inRecurrent urinary tract infections (UTI) are common in dogs and are associated with poor quality of life due to frequent and painful urination. Repeated courses of antibiotics lead to development of drug-resistant infections. Treatments targeted at preventing UTI would be ideal to avoid the poor quality of life and drug resistance associated with recurrent infections. Glycosaminoglycans (GAGs) lining the bladder surface have been shown to be important in maintaining a tight barrier to bacteria in