Does partial control of inflammation prevent long-term joint damage? Clinical rationale for combination therapy with multiple disease-modifying antirheumatic drugs.
نویسندگان
چکیده
Theodore Pincus, M.D., Professor of Medicine, Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Prof. Ferdinand C. Breedveld, MD, Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. Prof. Paul Emery, BA, MA, MBBChir, MD, FRCP, Rheumatology & Rehabilitation Unit, University of Leeds, Leeds, UK.
منابع مشابه
The importance of early treatment for the prognosis of rheumatoid arthritis.
Chronic synovial inflammation in rheumatoid arthritis (RA) leads to progressive damage to articular cartilage and bone, ultimately resulting in disability. Therefore, control of the articular inflammation is of great importance to prevent joint damage. A variety of disease-modifying antirheumatic drugs (DMARDs) are available for RA patients. Conventional synthetic DMARDs, and in particular biol...
متن کاملEmerging Treatments for Rheumatoid Arthritis:
Early treatment with disease-modifying anti-rheumatic drugs (DMARDs)--alone or in combination-can prevent joint damage and minimize disability. Until recently, the DMARDs used predominantly in patients with rheumatoid arthritis had been methotrexate, sulfasalazine, and hydoxychloroquine. Older DMARDs such as gold, d-penicillamine, and azathioprine have fallen out of favor because of their longt...
متن کاملSequential Combination Therapy Leading to Sustained Remission in a Patient with SAPHO Syndrome
The SAPHO syndrome represents a variety of clinically similar disorders with the key features of hyperostotic bone lesions in combination with chronic pustular skin disease. The respective pathophysiology of bone and joint manifestations in SAPHO syndrome is still a matter of discussion. For example it does not appear to represent reactive arthritis and HLA B27 antigen, with the latter being ty...
متن کاملEfficacy, tolerability and safety of biologic therapy in rheumatoid disease: patient considerations
Rheumatoid arthritis (RA) is a systemic inflammatory disease in which chronic inflammation leads to joint destruction and extra-articular complications. Early and effective inhibition of inflammation is critical in order to prevent the progressive joint damage that occurs rapidly after onset of the disease. In the past, treatment for this purpose was limited to conventional disease-modifying an...
متن کاملLong-term impact of early treatment on radiographic progression in rheumatoid arthritis: A meta-analysis.
OBJECTIVE Although early initiation of disease-modifying antirheumatic drugs (DMARDs) is effective in controlling short-term joint damage in individuals with rheumatoid arthritis (RA), the long-term benefit in disease progression is still controversial. We examined the long-term benefit of early DMARD initiation on radiographic progression in early RA. METHODS We identified published and unpu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical and experimental rheumatology
دوره 17 6 Suppl 18 شماره
صفحات -
تاریخ انتشار 1999