Hypothesis/Commentary Ancestry Estimation and Correction for Population Stratification in Molecular Epidemiologic Association Studies
نویسندگان
چکیده
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Trinity College Dublin, Dublin, Ireland; Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania; and Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
منابع مشابه
Ancestry estimation and correction for population stratification in molecular epidemiologic association studies.
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Trinity College Dublin, Dublin, Ireland; Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania; and Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Abramson Cancer Center, University of Pennsylvania School...
متن کاملPopulation Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data
Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not ubiquitous as ...
متن کاملFast model-based estimation of ancestry in unrelated individuals.
Population stratification has long been recognized as a confounding factor in genetic association studies. Estimated ancestries, derived from multi-locus genotype data, can be used to perform a statistical correction for population stratification. One popular technique for estimation of ancestry is the model-based approach embodied by the widely applied program structure. Another approach, impl...
متن کاملEstimating and adjusting for ancestry admixture in statistical methods for relatedness inference, heritability estimation, and association testing
It is well known that genetic association studies are not robust to population stratification. Two widely used approaches for the detection and correction of population structure are principal component analysis and model-based estimation of ancestry. These methods have been shown to give reliable inference on population structure in unrelated samples. We evaluated these two approaches in Mexic...
متن کاملMeasuring European population stratification with microarray genotype data.
A proper understanding of population genetic stratification--differences in individual ancestry within a population--is crucial in attempts to find genes for complex traits through association mapping. We report on genomewide typing of approximately 10,000 single-nucleotide polymorphisms in 297 individuals, to explore population structure in Europeans of known and unknown ancestry. The results ...
متن کامل